Metoprolol Related Compound C, auch bezeichnet als Metoprolol EP Impurity C und Bisoprolol EP Impurity L, ist das Hydrochlorid von 4-(2-Hydroxy-3-(isopropylamino)propoxy)benzaldehyd, CAS 1956321-87-1. Mit der Formel C13H19NO3.HCl und einer Molekülmasse von 237.30, 36.46 g/mol handelt es sich um eine aldehydische, beta-aryloxypropanolaminartige Verunreinigung, die aus unvollständiger Seitenkettenreduktion oder oxidativer Umwandlung bei Synthese und Lagerung von Beta-Blocker-Intermediaten entstehen kann. Wegen der reaktiven Carbonylfunktion erfolgt die Spurenanalytik typischerweise mittels LC-MS/MS und orthogonaler HPLC-Verfahren, ergänzt durch LC-HRMS zur Identitätsbestätigung und Verunreinigungszuordnung.
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