N-Nitroso Desmethyl Citalopram ist eine Nitrosamin-Verunreinigung, die aus der sekundären Aminvorstufe Desmethylcitalopram durch nitrosative Umsetzung während Synthese, Lagerung oder Kontakt mit nitrosierenden Agenzien entstehen kann. Mit der Summenformel C19H18FN3O2 und einer Molekülmasse von 339,4 g/mol gehört die Verbindung zur Klasse potenziell genotoxischer Verunreinigungen im Sinne der ICH-M7-Prinzipien, da Nitrosamine mit mutagenem Risiko assoziiert sind. Für den Nachweis und die Quantifizierung werden in der Regel hochselektive LC-MS/MS-Verfahren eingesetzt, häufig ergänzt durch hochauflösende Massenspektrometrie und gegebenenfalls GC-MS zur Bestätigung. Die Strukturzuordnung wird durch Spurenkonzentrationen, Isomerieeffekte und Nitritkontamination erschwert.
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To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
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The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
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