Das Dinitroso-Sumatriptan- bzw. N-Nitroso-Desmethyl-N-Nitroso-Sumatriptan-Impurity ist ein nitrosaminassoziiertes Abbau- und Nebenprodukt des Sumatriptan-Gerüsts mit der Summenformel C14H19N5O4S und einem Molekulargewicht von 353,40 g/mol. Die Bezeichnung weist auf mehrere N-Nitrosierungsstellen hin und spricht für eine Entstehung unter nitrosierenden Bedingungen, bei oxidativem Stress oder aus Synthesewegen mit Desmethyl-Vorstufen und sekundären Aminen. Als potenziell genotoxische Verunreinigung unterliegt es dem risikobasierten Kontrollansatz für Nitrosamine gemäß ICH M7. Die Spurenanalytik erfordert typischerweise LC-MS/MS, HRMS und chromatographische Orthogonalität zur Differenzierung isomerer Nitroso-Spezies.
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