Zusätzliche Informationen zu N-methyl-N-nitrosopropane-1 | 3-diamine
Parent drug
Nitroso inhouse impurity
IUPAC-Name
N-methyl-N-nitrosopropane-1,3-diamine
Synonyme
N/A
SMILES
NCCCN(C)N=O
InChI
InChI=1S/C4H11N3O/c1-7(6-8)4-2-3-5/h2-5H2,1H3
Beschreibung
N-methyl-N-nitrosopropane-1,3-diamin ist eine Nitrosamin-Verunreinigung mit der Summenformel C4H11N3O und einer Molekülmasse von 117,09 g/mol. Strukturell trägt es eine N-Nitroso-Funktion an einem Aminogerüst, ein Motiv, das mit metabolischer Aktivierung zu elektrophilen Spezies und damit mit genotoxischer Relevanz im Sinne von ICH M7 verbunden ist. Derartige Verbindungen können unter nitrosierenden Bedingungen während Synthese, Aufarbeitung oder Lagerung entstehen, wenn Aminvorstufen mit Nitrit in Kontakt kommen. Die Bestimmung im Spurenbereich erfordert üblicherweise GC-MS oder LC-MS/MS mit selektiver Ionenüberwachung und isotopenmarkierten internen Standards.
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To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
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Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
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