Omeprazol-Pyridon-Säure-Impurität, auch als Omeprazol-Hydrolyse-Impurität und SOM-Degradant-A bezeichnet, ist ein nicht genotoxisches, prozessbezogenes Abbauprodukt der Benzimidazol-Sulfoxid-Klasse, das unter hydrolytischem und oxidativem Stress entsteht, CAS 1227380-90-6. Sie entspricht C16H15N3O4 bei einer Molekülmasse von 313,31 g/mol. Das Pyridonsäure-Motiv spiegelt eine säurekatalysierte oder feuchtigkeitsvermittelte Umwandlung des Omeprazol-Gerüsts wider und ist daher eher ein Marker chemischer Instabilität als ein Synthesenebenprodukt. Die Charakterisierung erfordert üblicherweise LC-MS/MS, HRMS und ergänzend HPLC-UV; zur Strukturabsicherung werden in der Impuritätsprofilierung auch NMR-Daten eingesetzt.
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