Telmisartan EP-Verunreinigung F, auch als Telmisartanamid bezeichnet, ist die zugehörige Carboxamid-Prozessverunreinigung des biphenylischen Tetrazol-Antihypertensivums, CAS 915124-86-6. Mit der Summenformel C33H31N5O und einer Molekülmasse von 513,63 g/mol weist sie auf amidbildende Nebenreaktionen während der Synthese oder auf hydrolytische Umlagerungen aktivierter Zwischenstufen hin. Die Struktur enthält keine Nitrosaminfunktionalität, bleibt jedoch im Rahmen des Impurity-Profilings von Telmisartan regulatorisch relevant. Für den Nachweis und die Quantifizierung auf Spurenebene werden typischerweise LC-MS/MS, hochauflösende LC-MS und orthogonale HPLC-Verfahren eingesetzt, ergänzt durch NMR zur Strukturzuordnung.
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