CAS 696-23-1 bezeichnet 2-Methyl-5-nitroimidazol, eine nitroimidazolische heteroaromatische Verunreinigung, die auch als Metronidazol EP Impurity A, Metronidazol Benzoat EP Impurity B, Tinidazol Related Compound A und Ornidazol N-Desalkyl Impurity geführt wird. Mit der Summenformel C4H5N3O2 und einer Molmasse von 127,1 g/mol gehört die Verbindung zum 5-Nitroimidazol-Gerüst und kann als Synthesezwischenprodukt, als Carry-over-Verunreinigung oder als Dealkylierungsprodukt bei der Herstellung verwandter Antiinfektiva auftreten. Die Spurenbestimmung erfordert üblicherweise LC-MS/MS und, sofern geeignet, GC-MS; ergänzend werden UV- oder PDA-Detektion eingesetzt. Regulatorisch steht die Bewertung nach ICH M7 im Vordergrund.
References
Naguib, Ibrahim A., et al. “Partial Least Squares and Linear Support Vector Regression Chemometric Models for Analysis of Norfloxacin and Tinidazole with Tinidazole Impurity.” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 239, Oct. 2020, p. 118513, https://doi.org/10.1016/j.saa.2020.118513.
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