3-Hydroxy-Desoxydihydro Artemisinin (CAS 126641-61-0) es una impureza relevante en perfiles de calidad de productos a base de artemisinina | caracterizada por una modificación hidroxilada que altera polaridad y retención cromatográfica. Su presencia puede indicar degradación o rutas de reacción secundarias durante síntesis y almacenamiento | afectando pureza y rendimiento. Se detecta y cuantifica mediante HPLC con detección UV y confirmación por LC-MS/MS y RMN para identificación estructural. El control de esta impureza exige límites especificados | estudios de estabilidad y métodos validados de muestreo | extracción y cuantificación para asegurar cumplimiento regulatorio y seguridad del principio activo.
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