Impureza G de Clorhexidina digluconato (sal 2HCl) | CAS 165678-61-5 | corresponde a 1-(6-aminohexil)-5-(4-clorofenil)biguanida y se caracteriza como un subproducto estructural relevante en el perfil de impurezas. Presenta propiedades fisicoquímicas que alteran la polaridad y el comportamiento cromatográfico respecto al principio activo | lo que exige métodos analíticos específicos. Es detectable y cuantificable por HPLC-UV y LC-MS | y su identificación es crítica para el control de calidad | la validación de procesos y el establecimiento de especificaciones según Farmacopea Europea. Su monitorización aporta información sobre vías de degradación | controles de estabilidad y riesgos implicados en formulaciones.
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