Ethacrynic Acid Related Compound C; [4-[2-(α-Carboxy-2,3-dichloro-p-anisoyl)-2,5-diethyl-3,4-dihydro-2H-pyran-6-yl]-2,3-dichlorophenoxy]acetic Acid
Descripción
Impureza C de Etacrynic Acid EP (CAS 25355-92-4) | conocida también como Ethacrynic Acid Related Compound C y formalmente [4-[2-(α-Carboxy-2 | 3-dicloro-p-anisoyl)-2 | 5-dietil-3 | 4-dihidro-2H-piran-6-il]-2 | 3-diclorofenoxi]acético | es una impureza relevante en el control de calidad del etacrínico que requiere monitoreo analítico preciso; su estructura halogenada y la presencia de grupos carboxílicos influyen en la estabilidad y perfil de degradación del producto | pudiendo alterar especificaciones de pureza. Se recomienda su cuantificación mediante métodos validados como HPLC-UV y LC-MS | inclusión en límites de aceptación y estudios de degradación forzada para asegurar conformidad con monografías EP y minimizar riesgos en el desarrollo farmacéutico.
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