4′-(Azidomethyl)-[1 | 1′-biphenyl]-2-carboxylic acid (CAS 2758005-15-9) | conocido como Irbesartan Impurity 23 | es una impureza estructural relevante en el control de calidad de lotes farmacéuticos que contiene un grupo azida unido a un bifenilo carboxílico. Su perfil físico y químico incluye mayor apolaridad relativa al grupo carboxílico | solubilidad en disolventes polares-aproticos y baja solubilidad acuosa. Especificaciones analíticas típicas abarcan detección y cuantificación por HPLC con detección UV | LC-MS para confirmación de masa y RMN para verificación estructural. Consideraciones de estabilidad y precauciones en manejo por la función azida son críticas para el desarrollo de métodos de limpieza | eliminación y control de impurezas.
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