Indapamide Impurity 4 (CAS 604787-44-2) | conocido también como ácido benzoico 4-cloro-3-(etoxisulfonil) y reportado como Indapamide Impurity 14 y 24 | es una impureza estructural relevante en la síntesis de indapamida. Su presencia requiere monitoreo analítico riguroso por HPLC | LC-MS y RMN para establecer su perfil cromatográfico y espectrométrico y garantizar la pureza del principio activo. Desde el punto de vista regulatorio y de calidad | se evalúan su formación por vías de degradación o reacciones secundarias | su estabilidad y límites aceptables según guías de calidad farmacéutica | permitiendo optimizar procesos de purificación y control de lote.
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