Impureza 8-Amino[1»-(N»-dansyl)-4»-aminobutyl]-5′-(1-aziridinyl)-5′-deoxy adenosina (CAS 256953-68-1) identificada como subproducto en procesos sintéticos que involucran dansilación y aziridinación. Presenta un cromatograma característico en HPLC con señal por fluorescencia por el grupo dansil y masa molecular detectable por LC-MS | y muestra sensibilidad a condiciones ácidas que favorecen apertura del anillo aziridínico. Su presencia puede afectar especificaciones de pureza y requerir control mediante optimización de condiciones de reacción y etapas de purificación preparativa. Se recomienda monitoreo por HPLC-UV/FLD y confirmación estructural por espectrometría de masas y NMR para evaluación de riesgo y cumplimiento regulatorio.
Referencias
?Kunkel, Falk, et al. “A 7-Deazaadenosylaziridine Cofactor for Sequence-Specific Labeling of DNA by the DNA Cytosine-C5 Methyltransferase M.HhaI.†Molecules, vol. 20, no. 11, Nov. 2015, pp. 20805–22,  https://doi.org/10.3390/molecules201119723.
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![8-Amino[1''-(N''-dansyl)-4''-aminobutyl]-5'-(1-aziridinyl)-5'-deoxy adenosine](https://veeprho.com/wp-content/uploads/2022/07/8-Amino5B1-N-dansyl-4-aminobutyl5D-5-1-aziridinyl-5-deoxy-adenosine-sqr.png "8-Amino[1''-(N''-dansyl)-4''-aminobutyl]-5'-(1-aziridinyl)-5'-deoxy adenosine")
