El ácido acético (CAS 64-19-7) como impureza constituye un riesgo crítico en la producción química y farmacéutica por su acidez | capacidad de corrosión y propensión a catalizar reacciones de hidrólisis y transesterificación que degradan materias primas y productos intermedios. Su presencia en trazas altera especificaciones | contamina catalizadores y afecta la estabilidad organoléptica y química. La monitorización se realiza mediante titulaciones ácido-base | cromatografía de gases con detector selectivo y HPLC tras derivatización | así como espectroscopía IR. Su eliminación requiere destilación fraccionada | lavado acuoso | resinas de intercambio iónico o carbón activado según la matriz del producto.
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