La impureza E del ácido alfa lipoico, también designada impureza 10 del ácido tióctico, es una impureza azufrada asociada con la química de proceso o de degradación del sistema ditiolano lipofílico del ácido alfa lipoico. El compuesto, CAS 2114407-82-6, presenta fórmula molecular C8H14O3S2 y peso molecular de 222.3 g/mol. Su estructura es compatible con un derivado oxidado o reordenado del ácido tióctico más que con un motivo genotóxico clásico. La cuantificación en nivel traza suele requerir LC-MS/MS o LC-MS de alta resolución, con HPLC-UV o GC-MS complementarios según la complejidad de la matriz. Su caracterización respalda el perfil de impurezas bajo marcos farmacopéicos e ICH.
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