El compuesto identificado como Metoprolol EP Impurity H, también denominado O-Desmethyl Metoprolol o Betaxolol Hydroxyethyl Analog (CAS 62572-94-5), es una impureza relevante en el control de calidad de materias primas y formulaciones relacionadas con metoprolol y betaxolol. Su estructura incorpora un grupo hidroxietil unido al anillo fenoxi y una cadena propanolamina terciaria, lo que afecta solubilidad y perfil de retención cromatográfica. Se reporta como producto de desmetilación o reacciones secundarias durante síntesis y degradación. Su identificación y cuantificación se realiza por HPLC con detección UV, espectrometría de masas y RMN para garantizar cumplimiento de límites de impurezas y estabilidad del lote.
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