La impureza EP I de buspirona, también denominada buspirona clorobuspirona, es una impureza clorada de proceso asociada al ansiolítico azaspirodecandiona buspirona. El CAS 2725354-99-2 corresponde a C21H30ClN5O2, con peso molecular de 419.95 g/mol. La presencia de cloro indica un subproducto sintético halogenado o un producto de sustitución formado en etapas intermedias dependientes de la ruta o por química de reacción secundaria. Su resolución cromatográfica suele requerir HPLC en fase reversa con confirmación por LC-MS/MS o espectrometría de masas de alta resolución, y la elucidación estructural puede apoyarse en RMN. Se controla dentro de perfiles regulatorios de impurezas y límites de especificación.
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