La impureza Valsartan Desvaleryl (CAS 676129-92-3) | también conocida como Des(oxopentyl) Valsartan o (S)-2-(((2′-(2H-Tetrazol-5-yl)-[1 | 1′-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid | es un degradante estructural de valsartán caracterizado por la pérdida del residuo oxopentilo. Este contaminante presenta mayor polaridad y acidez que el principio activo | lo que influye en solubilidad | perfil de disolución y estabilidad del lote. Su identificación y cuantificación requieren técnicas cromatográficas avanzadas y espectrometría de masas | con límites de aceptación definidos por normas regulatorias. La vigilancia analítica y estrategias de control son esenciales para asegurar calidad y cumplimiento.
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