La impureza cloroacetil de diclofenaco (CAS 15308-01-7) | conocida también como 2 | 2′ | 6′-Tricloro-N-fenilacetanilida o N-(Cloroacetil)-2 | 6-diclorodifenilamina | es una impureza sintética relevante en procesos de fabricación de diclofenaco. Su estructura cloroacetilada y sustitución triclorada confieren mayor lipofilia y potencial retención en fases cremas y sólidos. Se monitorea por cromatografía líquida de alta resolución | espectrometría de masas y resonancia magnética nuclear para identificar su perfil y cuantificar niveles traza. La presencia de esta impureza puede afectar pureza | estabilidad y cumplimiento de especificaciones regulatorias | por lo que se establecen límites de control | métodos de eliminación y estudios de degradación dirigidos.
Referencias
Orlandini, S., et al. “A Comprehensive Strategy in the Development of a Cyclodextrin-Modified Microemulsion Electrokinetic Chromatographic Method for the Assay of Diclofenac and Its Impurities: Mixture-Process Variable Experiments and Quality by Design.†Journal of Chromatography A, vol. 1466, Sept. 2016, pp. 189–98, https://doi.org/10.1016/j.chroma.2016.09.013.?Davies, Neal M., and Keith E. Anderson. “Clinical Pharmacokinetics of Diclofenac.†Clinical Pharmacokinetics, vol. 33, no. 3, Sept. 1997
Solicitar cotización
"*" señala los campos obligatorios
Otros productos relacionados con Diclofenac impurities
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Siempre activo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Siempre activo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
