La impureza Diethyl Phthalate (CAS 84-66-2) es un éster ftalato de bajo peso molecular que aparece como un líquido aceitoso incoloro con baja solubilidad en agua y buena miscibilidad en solventes orgánicos. Suele originarse por contaminación de plastificantes | residuos de síntesis o migración desde materiales de envasado y puede afectar la estabilidad | olor y perfil químico del producto final. Su detección se realiza típicamente por GC-MS | HPLC y espectroscopía infrarroja | con límites de aceptación establecidos en ppm según normativa. El control y eliminación se efectúan mediante destilación fraccionada | adsorción en carbono activo y purificación cromatográfica para cumplir requisitos de calidad y seguridad.
Referencias
Alfaro, Robert A., and Donald D. Davis. “Diclofenac.†Nih.gov, StatPearls Publishing, 3 June 2021, www.ncbi.nlm.nih.gov/books/NBK557879/. ‌
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