Eltrombopag Impurity 15 (CAS 376592-58-4) es una sustancia relacionada definida del agonista del receptor de trombopoyetina de molécula pequeña eltrombopag, con fórmula molecular C13H8ClNO5 y peso molecular de 293.66 g/mol. Su estructura es compatible con un impurity aromático clorado y altamente oxigenado, derivado de degradación o intermedio de síntesis, más que con una simple forma salina. Estas especies se vigilan por su aparición en condiciones de estrés oxidativo y por su comportamiento cromatográfico particular. La detección y cuantificación suelen requerir LC-MS/MS, LC-MS de alta resolución y métodos HPLC-UV ortogonales en el perfil de impurezas.
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