La impureza EP B de ibuprofeno, identificada como p-butyl ibuprofeno, es una impureza isomérica de ácido arilpropiónico asociada a la ruta de fabricación del ibuprofeno y puede originarse por alquilación incompleta o arrastre regioisomérico durante la acilación de Friedel-Crafts y las transformaciones posteriores de la cadena lateral. El CAS 3585-49-7 corresponde a la fórmula molecular C13H18O2 y al peso molecular de 206.29 g/mol. Como impureza estructural no genotóxica, su relevancia es principalmente farmacopeica y composicional. Su cuantificación a nivel traza suele requerir HPLC en fase reversa con detección UV, confirmada por LC-MS o GC-MS cuando se necesita discriminar isómeros.
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