Impureza Ibuprofeno EP Impurity G (CAS 1391054-15-1) | también denominada Ibuprofen BP Impurity G | Ibuprofen Dimer o trans-Ibuprofen Impurity G | es un dímero estructuralmente definido del ibuprofeno (6-(2-methylpropyl)-4-[4-(2-methylpropyl)phenyl]-2 | 3-dihidro-1H-naphthalene-1 | 4-dicarboxylic acid) que puede formarse por dimerización durante síntesis | reacción de acoplamiento o almacenamiento. Desde el punto de vista analítico exige métodos específicos de control como HPLC con detectores UV | LC-MS y RMN para identificación inequívoca y cuantificación. Su presencia afecta la pureza | el perfil de impurezas y la estabilidad del lote | por lo que se recomienda establecer especificaciones según EP/BP y aplicar medidas de control de proceso y purificación para minimizar su formación.
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