Indomethacin acyl glucuronide es una impureza metabolítica y de proceso relevante en el perfil de degradación de indometacina | que requiere identificación y cuantificación precisas por su posible interconversión con el principio activo. Su caracterización analítica se realiza mediante técnicas como LC-MS/MS | HPLC con detección UV y espectrometría de alta resolución combinada con RMN para confirmar estructura y posiciones de conjugación. En estudios de estabilidad y forced degradation | este conjugado puede influir en la pureza declarada y en la evaluación de seguridad | por lo que se integra en estrategias de control de calidad y límites según guías regulatorias aplicables.
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