La L-tirosina, también denominada Levodopa EP Impurity B y Phenylalanine EP Impurity C, es el aminoácido aromático 4-hidroxi-L-fenilalanina (CAS 60-18-4), con fórmula molecular C9H11NO3 y peso molecular de 181.07 g/mol. Estructuralmente corresponde a un derivado de fenilalanina hidroxilado en posición para, estrechamente vinculado por biosíntesis y degradación con los precursores de catecolaminas. En el contexto farmacopeico, puede presentarse como impureza relacionada con el proceso o como resultado de conversión incompleta, hidrólisis u oxidación en cadenas de fabricación de levodopa y fenilalanina. Su elucidación suele requerir LC-MS/MS, LC-UV y, para niveles traza, HRMS o métodos de LC quiral.
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