Maribavir Impurity 4 (CAS 176161-18-5) es una impureza relevante en el control del proceso sintético de maribavir que requiere monitoreo riguroso. Se caracteriza por un perfil cromatográfico y espectrométrico distintivo, detectada por HPLC con detección UV y confirmada mediante LC-MS y RMN para la identificación estructural. Su aparición suele relacionarse con rutas de degradación o etapas de reacción incompletas, pudiendo afectar la conformidad del lote si supera los límites establecidos. El análisis cuantitativo y ensayos acelerados de estabilidad permiten definir límites de aceptación, optimizar condiciones de síntesis y minimizar su formación mediante ajustes de pH, tiempo y purificación.
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