10 synthesis attempts under recommended conditions for nitroso impurity formation. Along with HPLC, MASS/LCMS, NMR, IR performed for all 10 experiments
Report Format
Delivered in digital PDF format. Printed copies available on request (additional shipping and handling charges apply).
Report Language
English by default. Certified translations available at extra cost via our third-party translation partner.
Descripción
N-Nitroso Abemaciclib es una impureza nitrosamina propuesta relacionada con abemaciclib, un inhibidor de CDK4/6 utilizado en oncología. La impureza se considera un posible producto de nitrosación de una unidad que contiene nitrógeno o es nitrosable nitrosable que, en presencia de agentes nitrosantes (p. ej., nitrito/ácido nitroso) bajo condiciones ácidas, podría formar el derivado N-nitroso correspondiente.
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