Impureza F de fenilefrina | identificada como ácido 2-naftalenoacético (2-NAA | CAS 581-96-4) | es una impureza estructural observada en materias primas e intermedios de síntesis. Sus características fisicoquímicas influyen en el perfil de impurezas y en la separación cromatográfica | por lo que su cuantificación por HPLC con detector UV o MS y su confirmación por RMN son esenciales para el control de calidad. Las especificaciones analíticas deben definir límites aceptables | métodos de remoción y estudios de degradación forzada que clarifiquen su origen y estabilidad. Una identificación y cuantificación precisas reducen riesgos regulatorios y de seguridad.
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