La impureza (R)-3-(Bromomethyl)hexanoyl Chloride (CAS 2101641-94-3) presenta alta reactividad por su funcionalidad de acil cloruro y un grupo bromometilo en posición 3 | lo que la hace susceptible a hidrólisis y a formación de HBr bajo condiciones húmedas. Puede originarse por conversión incompleta o bromación lateral durante la síntesis y contribuir a racemización si no se controla la temperatura. Su presencia afecta acoplamientos subsiguientes y la pureza en etapas intermedias; se monitoriza por GC | LC-MS y RMN y se controla mediante destilación a vacío | cromatografía y manejo en atmósfera inerte a baja temperatura.
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