Impureza Descloro de Sorafenib (CAS 1285533-84-7) es un subproducto crítico en el perfil de impurezas del proceso de síntesis de Sorafenib que requiere monitoreo riguroso. Químicamente definida por la pérdida del átomo de cloro en la estructura fenil | presenta propiedades fisicoquímicas y espectrales específicas que permiten su identificación y cuantificación mediante HPLC con detección UV | LC-MS para confirmación de masa y RMN para elucidación estructural. La presencia de esta impureza puede afectar la pureza del principio activo y la estabilidad del lote por lo que se recomienda establecer límites especificados | métodos validados y estudios de degradación forzados para control y mitigación en desarrollo y fabricación.
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