La Impureza Dioxo de Vareniclina (CAS 357424-07-8) es un subproducto oxidativo definido asociado con la transformación del heterociclo de la vareniclina, coherente con una degradación secuencial por N-óxido y formación de carbonilos más que con un simple residuo de proceso. Presenta fórmula molecular C13H13N3O2 y peso molecular de 243.26 g/mol. Su estructura heteroaromática polar suele requerir LC-MS/MS para la caracterización a nivel traza, mientras que LC-HRMS aporta confirmación elemental y perfilado de impurezas. En estudios de estabilidad se vigila como degradante relacionado estructuralmente para evaluar vías de oxidación y especificidad del método conforme a expectativas regulatorias de control de impurezas.
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