Vildagliptin Chloroacetyl Nitrile (S)-Isomer (CAS 207557-35-5) es una impureza quiral relevante en la síntesis de vildagliptina | caracterizada por un anillo pirrolidínico sustituido con un grupo cloroacetil y nitrilo en configuración (S). Su presencia puede afectar rendimientos y perfiles de seguridad | por lo que se requiere control riguroso por HPLC y cromatografía quiral para cuantificación y resolución de epímeros. Es químicamente reactiva por el grupo cloroacetilo | sensible a hidrólisis y puede formarse por desprotección incompleta o reacciones secundarias. Se recomienda controles de proceso | límites especificados en la validación y manejo con medidas estándar de seguridad y almacenamiento en frío seco.
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