Ziprasidone Related Compound A; 3-(Piperazin-1-yl)benzoisothiazole; N-(3-Benzisothiazolyl)piperazine; 1-(1, 2-Benzisothiazol-3-yl)piperazine; Ziprasidone EP Impurity A;
SMILES
C1CN(CCN1)C2=NSC3=CC=CC=C32.Cl
Descripción
La impureza A de ziprasidona EP, también denominada Ziprasidone Related Compound A, es la sal clorhidrato del precursor benzisotiazólico correspondiente al CAS 87691-88-1, con fórmula C11H13N3S · HCl y peso molecular de 255.77 g/mol. Se considera una impureza de proceso o precursor residual más que un producto clásico de degradación. En el perfil de impurezas, esta especie se distingue por su heterociclo básico y polar, y su cuantificación a nivel de traza suele requerir LC-MS/MS, con LC-UV como soporte ortogonal. Su especificación es pertinente para el control regulatorio de sustancias relacionadas y para evaluar ciclación incompleta o formación de sal durante la fabricación.
Referencias
Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile By Anne W Schmidt, Lorraine A Lebel, Harry R Howard, Stevin H Zorn Container: European Journal of Pharmacology Year: 2001 Volume: 425 Issue: 3 DOI: 10.1016/s0014-2999(01)01188-8 URL: https://www.sciencedirect.com/science/article/abs/pii/S0014299901011888
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