16219-99-14-nitrosomethylaminopyridine (NMAP)

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Catalogue No.:	VE006116
CAS No.:	16219-99-1
Mol. Formula:	C6H7N3O
Mol. Weight:	137.14 g/mol

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Additional information on CAS 16219-99-1

Parent drug

Nitroso/ Valsartan

IUPAC Name

4-nitrosomethylaminopyridine

Pharmacopoeial Synonyms

N/A

Other Synonyms

N-methyl-N-pyridin-4-ylnitrous amide; N-methyl-N-nitrosopyridin-4-amine

Smile

CN(C1=CC=NC=C1)N=O

InChI

InChI=1S/C6H7N3O/c1-9(8-10)6-2-4-7-5-3-6/h2-5H,1H3

Shipping Condition

Ambient Temperature

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Additional Characterization Data

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

Description

4-Nitrosomethylaminopyridine (NMAP), CAS 16219-99-1, is a pyridyl nitrosamine impurity with the molecular formula C6H7N3O and molecular weight 137.14 g/mol. As an N-nitrosated aminopyridine, it is structurally associated with potent electrophilic behavior and a genotoxicity concern consistent with the broader nitrosamine class. Such species may arise from nitrosation of corresponding aminated precursors during synthesis or storage under nitrosating conditions. Regulatory assessment generally aligns with ICH M7 principles for DNA-reactive impurities. Trace-level determination typically requires LC-MS/MS, GC-MS, or high-resolution MS, often with careful control of matrix effects and method selectivity.