Apixaban Methyl Ester Impurity, also known as Apixaban Related Compound E, in various pharmacopoeias, is a highly characterized standard. It meets strict regulatory requirements set by USP, EMA, JP, and BP, making it a crucial component in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Apixaban. Apixaban Methyl Ester Impurity (CAS No: 1074365-84-6) or 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl) phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid methyl ester is a pyrazole derivative, it acts as Inhibition of factor Xa leads to decreased conversion of factor II to IIa, resulting in decreased thrombin generation and used in the treatment and prevent strokes or blood clots.
References
Hurst, Katherine, et al. “Quick Reference Guide to Apixaban.†Vascular Health and Risk Management, vol. Volume 13, July 2017, pp. 263–267, 10.2147/vhrm.s121944.
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![5-((4-(3-carbamoyl-1-(4-methoxy phenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)phenyl) (nitroso) amino) pentanoic acid](https://veeprho.com/wp-content/uploads/2023/06/5-4-3-carbamoyl-1-4-methoxy-phenyl-7-oxo-1-4-5-7-tetrahydro-6H-pyrazolo-3-4-c-pyridin-6-yl-phenyl-nitroso-amino-pentanoic20acid.png "5-((4-(3-carbamoyl-1-(4-methoxy phenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)phenyl) (nitroso) amino) pentanoic acid")
