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821-48-7Cyclophosphamide Related Compound A (HCl Salt)
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| Catalogue No.: | VL165001 |
|---|---|
| CAS No.: | 821-48-7 |
| Mol. Formula: | C4H10Cl3N |
| Mol. Weight: | 178.49 g/mol |
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Additional information on CAS 821-48-7
Parent drug
CyclophosphamideIUPAC Name
Bis(2-Chloroethyl)amine hydrochloridePharmacopeial Synonyms
N/ASynonyms
2-Chloro-N-(2-chloroethyl)ethanamine HydrochlorideSmiles
ClCCNCCCl[HCl]InChI
InChI=1S/C4H9Cl2N.ClH/c5-1-3-7-4-2-6;/h7H,1-4H2;1HShipping Condition
Ambient TemperatureCharacterization Data (Included)
HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).Additional Characterization Data
QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.Description
Cyclophosphamide Related Compound A, identified as bis(2-chloroethyl)amine hydrochloride, CAS 821-48-7, is a small haloalkylamine impurity with molecular formula C4H10Cl3N and molecular weight 178.49 g/mol. It represents a structurally relevant alkylating precursor and potential process-related byproduct associated with cyclophosphamide synthesis or hydrolytic degradation of chloroethylamine intermediates. Owing to its electrophilic bis(2-chloroethyl)amine motif, it is regarded within the broader genotoxic impurity context and may warrant evaluation under ICH M7 principles. Determination typically requires highly selective methods such as LC-MS/MS or GC-MS, with chromatographic resolution needed because of its volatility, reactivity, and closely related amine impurities.References
“N-PHOSPHORYLATED NITROGEN MUSTARDS; PREPARATION of 2-CHLOROETHYL- and BIS(2-CHLOROETHYL)-AMIDES with the BENZODIAZAPHOSPHORINONE RING SYSTEM.” Phosphorus, Sulfur, and Silicon and the Related Elements, 2021, www.tandfonline.com/doi/abs/10.1080/10426509708043542.CHAMBERS, BENJAMIN M. “TREATMENT of GIANT FOLLICULAR LYMPHOMA with NITROGEN MUSTARD (METHYL-BIS-[2-CHLOROETHYL] AMINE).” Archives of Ophthalmology, vol. 43, no. 3, Mar. 1950, p. 520, https://doi.org/10.1001/archopht.1950.00910010529012.Request a Quote
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