100% accuracy
of data
of data
24/7 scientific
support
support
0% tolerance in
quality of product
quality of product
Stock Locations
- New Jersey, USA
- Czech Republic, EU
- Mumbai, India
* Stock subject to availability.
2169998-23-4Dapagliflozin Keto Impurity
● In Stock
| Catalogue No.: | VL1650008 |
|---|---|
| CAS No.: | 2169998-23-4 |
| Mol. Formula: | C21H23ClO7 |
| Mol. Weight: | 422.86 g/mol |
Order Online
Additional information on CAS 2169998-23-4
Parent drug
DapagliflozinIUPAC Name
(6-chloro-3-β-D-glucopyranosylphenyl)(4- ethoxyphenyl)methanonePharmacopoeial Synonyms
Dapagliflozin FP Impurity COther Synonyms
Dapagliflozin Related Compound 4Smiles
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](C2=CC(C(C3=CC=C(OCC)C=C3)=O)=C(Cl)C=C2)O1InChI
InChI=1S/C21H23ClO7/c1-2-28-13-6-3-11(4-7-13)17(24)14-9-12(5-8-15(14)22)21-20(27)19(26)18(25)16(10-23)29-21/h3-9,16,18-21,23,25-27H,2,10H2,1H3/t16-,18-,19+,20-,21+/m1/s1Description
Dapagliflozin Keto Impurity, also designated Dapagliflozin Related Compound 4 and Dapagliflozin FP Impurity C, is a process-related carbonyl analogue of the sodium-glucose cotransporter 2 inhibitor dapagliflozin. CAS 2169998-23-4 corresponds to C21H23ClO7, molecular weight 422.86 g/mol. Structurally, it reflects oxidation at the benzylic/ketal region of the empagliflozin-like glucopyranoside scaffold, consistent with synthetic over-oxidation or storage-mediated degradation. It is not a nitrosamine, yet its characterization remains relevant under impurity control expectations. Trace determination generally requires LC-MS/MS, HR-LC-MS, and orthogonal HPLC-UV methods, with NMR used for structural confirmation.References
“Facile and Green Synthesis of Dapagliflozin.†Synthetic Communications, 2019, www.tandfonline.com/doi/abs/10.1080/00397911.2019.1666283.“Long-Term Efficacy of Dapagliflozin in Patients with Type 2 Diabetes Mellitus Receiving High Doses of Insulin: A Randomized Trial: Annals of Internal Medicine: Vol 156, No 6.†Annals of Internal Medicine, 2012, www.acpjournals.org/doi/full/10.7326/0003-4819-156-6-201203200-00003.Request a Quote
« * » indique les champs nécessaires
Other products related to Dapagliflozin impurities
Impurity structure
Parent Drug Name
CAS No.
Name of Impurity
Catalog No.
Dapagliflozin
CAS No. 2176485-21-3
Cat No. VE008721
Dapagliflozin
CAS No. N/A
Cat No. VE009529
