Leflunomide Related Compound C, also designated Leflunomide EP Impurity C and Leflunomide meta-Isomer, is the positional meta-isomer associated with the leflunomide synthetic impurity profile. CAS 61643-23-0 identifies a fluorinated pyridine amide derivative with molecular formula C12H9F3N2O2 and molecular weight 270.21 g/mol. Its occurrence is typically attributed to isomeric carryover or regioselective side-product formation during assembly of the trifluoromethyl pyridine scaffold. Owing to its structural proximity to the active substance, trace-level determination generally relies on LC-MS/MS and, where required, high-resolution LC-MS combined with chromatographic separation against related isomers.
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