5233-42-1: 5 chlorohydrochlorothiazide
5-Chlorohydrochlorothiazide (CAS No.: 5233-42-1) is a potential impurity reported in the hydrochlorothiazide drug substance. Hydrochlorothiazide is a thiazide-type diuretic. It decreases blood pressure by blocking the sodium/chloride cotransporter in the early segment of the distal convoluted tubule.
Additional information on CAS 5233-42-1
VL80004
5233-42-1
C7H7Cl2N3O4S2
332.18
Hydrochlorothiazide
5, 6-Dichloro-3, 4-dihydro-2H-1, 2, 4-benzothiadiazine-7-sulfonamide 1, 1-Dioxide
5-chlorohydrochlorothiazide; 5, 6-Dichloro-3, 4-dihydro-2H-1, 2, 4-benzothiadiazine-7-sulfonamide 1, 1-Dioxide; Hydrochlorothiazide 5-Chloro Impurity
Desai, Pritesh R., et al. “Stability Indicating RP-HPLC Method Development and Validation for Simultaneous Quantification of 15 Organic Impurities of Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide in Combined Dosage Form.” Chromatographia, vol. 82, no. 5, Apr. 2019, pp. 819–33, https://doi.org/10.1007/s10337-019-03718-9.
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