7-(Hydroxymethyl)tetrahydrobiopterin
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Documentation

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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

7-(Hydroxymethyl)tetrahydrobiopterin

● Under Development

Catalogue No.:VE008665
CAS No.:N/A
Mol. Formula:C10H19N5O4
Mol. Weight:273.29 g/mol

Additional information on 7-(Hydroxymethyl)tetrahydrobiopterin

Parent drug

Sapropterin

IUPAC Name

(6R)-2-amino-6-((1R, 2S)-1, 2-dihydroxypropyl)-7-(hydroxymethyl)-2, 3, 5, 6, 7, 8-hexahydropteridin-4(1H)-one

Synonyms

N/A

Description

7-(Hydroxymethyl)tetrahydrobiopterin with IUPAC Name (6R) -2-amino-6 - ((1R, 2S) -1,2-dihydroxypropyl) -7- (hydroxymethyl) -2,3,5,6,7,8-hexahydropteridin-4 (1H) -one is an impurity of Sapropterin. Sapropterin is synthetic 6R-tetrahydrobiopterin (6R-BH4), a cofactor for phenylalanine hydroxylase, which is the reason that it restores the activity of phenylalanine hydroxylase as well as reduces phenylalanine concentration in the blood.

References

NICE. “BNF: British National Formulary – NICE.” Nice.org.uk, NICE, 2021, bnf.nice.org.uk/drug/sapropterin-dihydrochloride.html

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