Sapropterin Nitroso Impurity 3

Status: Under Development

Sapropterin Nitroso Impurity 3 or (R)-2-Amino-6-((1R, 2S)-1, 2-dihydroxypropyl)-5-nitroso-5, 6, 7, 8-tetrahydropteridin-4(1H)-one, Sapropterin Nitroso Impurity 3 it is an impurity present in Sapropterin, Sapropterin is a cofactor in the synthesis of nitric oxide, which is essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase, the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase, which is a natural co-factor or co-enzyme for phenylalanine-4-hydroxylase, used in the treatment of phenylketonuria.

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Additional information on Sapropterin Nitroso Impurity 3

Catalogue No. VE008522
CAS No. N/A
Molecular Formula C9H14N6O4
Molecular Weight 270.2 g/mol
Parent drug Sapropterin
IUPAC Name (R)-2-Amino-6-((1R, 2S)-1, 2-dihydroxypropyl)-5-nitroso-5, 6, 7, 8-tetrahydropteridin-4(1H)-one
Synonyms N/A
References "Qu, J., Yang, T., Wang, E., Li, M., Chen, C., Ma, L., … Cui, Y. (2019). Efficacy and safety of sapropterin dihydrochloride in patients with phenylketonuria: A meta‐analysis of randomized controlled trials. British Journal of Clinical Pharmacology, 85(5), 893–899. https://doi.org/10.1111/bcp.13886 ‌"
Status Under Development

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