Sapropterin Nitroso Impurity 3

Sapropterin Nitroso Impurity 3 or (R)-2-Amino-6-((1R, 2S)-1, 2-dihydroxypropyl)-5-nitroso-5, 6, 7, 8-tetrahydropteridin-4(1H)-one, Sapropterin Nitroso Impurity 3 it is an impurity present in Sapropterin, Sapropterin is a cofactor in the synthesis of nitric oxide, which is essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase, the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase, which is a natural co-factor or co-enzyme for phenylalanine-4-hydroxylase, used in the treatment of phenylketonuria.

Additional information

Catalogue No.

VE008522

CAS No.

N/A

Molecular Formula

C9H14N6O4

Molecular Weight

270.2 g/mol

IUPAC Name

(R)-2-Amino-6-((1R, 2S)-1, 2-dihydroxypropyl)-5-nitroso-5, 6, 7, 8-tetrahydropteridin-4(1H)-one

References

"Qu, J., Yang, T., Wang, E., Li, M., Chen, C., Ma, L., … Cui, Y. (2019). Efficacy and safety of sapropterin dihydrochloride in patients with phenylketonuria: A meta‐analysis of randomized controlled trials. British Journal of Clinical Pharmacology, 85(5), 893–899. https://doi.org/10.1111/bcp.13886 ‌"

Status

Under Development