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79108-51-3N-Nitroso Vildagliptin L-Prolinaminde

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Catalogue No.:	VE0010445
CAS No.:	79108-51-3
Mol. Formula:	C5H9N3O2
Mol. Weight:	143.1 g/mol

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Additional information on CAS 79108-51-3

Parent drug

Vildagliptin

IUPAC Name

(S)-1-Nitrosopyrrolidine-2-Carboxamide

Pharmacopoeial Synonyms

N/A

Other Synonyms

Vildagliptin N-Nitroso-L-Prolinaminde

Smile

O=C([C@H]1N(N=O)CCC1)N

InChI

InChI=1S/C5H9N3O2/c6-5(9)4-2-1-3-8(4)7-10/h4H,1-3H2,(H2,6,9)/t4-/m0/s1

Description

N-Nitroso Vildagliptin L-Prolinamide, also described as Vildagliptin N-Nitroso-L-Prolinamide, is a nitrosamine-related impurity with CAS 79108-51-3, molecular formula C5H9N3O2, and molecular weight 143.1 g/mol. As an N-nitroso derivative of a prolinamide fragment, it is relevant to nitrosation chemistry arising from exposure of amine-containing intermediates to nitrosating agents during synthesis or storage. Such species are evaluated under ICH M7 because of potential mutagenic and genotoxic concern. Trace-level measurement generally requires LC-MS/MS, often complemented by high-resolution LC-MS or GC-MS after suitable derivatization, to resolve low-ng thresholds and confirm identity in complex pharmaceutical matrices.