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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

1180132-17-5Abemaciclib Impurity 1

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Catalogue No.:	VE0017758
CAS No.:	1180132-17-5
Mol. Formula:	C12H20N4
Mol. Weight:	220.3 g/mol

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Additional information on CAS 1180132-17-5

Parent drug

Abemaciclib

IUPAC Name

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

Pharmacopeial Synonyms

N/A

Synonyms

2-Pyridinamine, 5-[(4-ethyl-1-piperazinyl)methyl]-; 2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine; 5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine;

Smiles

NC1=NC=C(CN2CCN(CC)CC2)C=C1

InChI

InChI=1S/C12H20N4/c1-2-15-5-7-16(8-6-15)10-11-3-4-12(13)14-9-11/h3-4,9H,2,5-8,10H2,1H3,(H2,13,14)

Shipping Condition

Ambient Temperature

Description

Abemaciclib Impurity 1 (CAS 1180132-17-5) is a 2-pyridinamine derivative bearing a 5-(4-ethyl-1-piperazinyl)methyl substituent, also referenced as 2-amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine and 5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine. Its heterocyclic, multi-amine structure increases polarity and basicity relative to the parent API, which alters chromatographic retention, solubility and mass spectrometric ionization behavior. This process- and degradation-related impurity is critical for impurity profiling, method development and specification setting because of its potential impact on purity and stability. Characterization typically relies on orthogonal analytical approaches such as HPLC-UV and LC-MS to ensure accurate quantification and regulatory compliance.