Alanylglutamic Acid, CAS 13187-90-1, is a defined dipeptidic impurity composed of alanine and glutamic acid residues with molecular formula C8H14N2O5 and molecular weight 218.21 g/mol. It is generally associated with peptide coupling side reactions, incomplete deprotection, or partial sequence carryover during synthesis of amino acid derivatives and related actives. As a polar zwitterionic species, it exhibits low volatility and is typically characterized by LC-MS/MS or HILIC coupled to high-resolution MS, with orthogonal confirmation by ion-exchange or derivatization LC methods. Its occurrence is evaluated as a process-related impurity rather than a genotoxic alert.
References
Schiesel, Simone, et al. “Quantitative High-Performance Liquid Chromatography–Tandem Mass Spectrometry Impurity Profiling Methods for the Analysis of Parenteral Infusion Solutions for Amino Acid Supplementation Containing L-Alanyl-l-Glutamine.†Journal of Chromatography A, vol. 1259, Oct. 2012, pp. 111–20,  https://doi.org/10.1016/j.chroma.2012.01.020.
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