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268221-76-7Cyclo (L-Ala-L-Gln)
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| Catalogue No.: | VL5630001 |
|---|---|
| CAS No.: | 268221-76-7 |
| Mol. Formula: | C8H13N3O3 |
| Mol. Weight: | 199.21 g/mol |
Additional information on CAS 268221-76-7
Parent drug
AlanineIUPAC Name
3-((2S,5S)-5-methyl-3,6-dioxopiperazin-2-yl)propanamideSynonyms
N/ADescription
Cyclo (L-Ala-L-Gln), CAS 268221-76-7, is a diketopiperazine impurity arising from intramolecular cyclization of the dipeptide L-alanyl-L-glutamine during synthesis, storage, or acid- and heat-assisted degradation. With molecular formula C8H13N3O3 and molecular weight 199.21 g/mol, it represents a structurally defined cyclic dipeptide rather than a process-related volatile contaminant. Its nonvolatile, polar heterocyclic nature typically requires LC-MS/MS for sensitive identification and quantitative impurity profiling, with supporting confirmation by high-resolution MS and, where needed, NMR. In regulated specifications, such peptide-derived impurities are assessed as potential degradants and monitored according to impurity control principles.References
Schiesel, Simone, et al. “Quantitative High-Performance Liquid Chromatography–Tandem Mass Spectrometry Impurity Profiling Methods for the Analysis of Parenteral Infusion Solutions for Amino Acid Supplementation Containing L-Alanyl-l-Glutamine.â€Â Journal of Chromatography A, vol. 1259, Oct. 2012, pp. 111–20,  https://doi.org/10.1016/j.chroma.2012.01.020.Request a Quote
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