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81403-69-2Alfuzosin EP Impurity D (HCl Salt)
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| Catalogue No.: | VL259003 |
|---|---|
| CAS No.: | 81403-69-2 |
| Mol. Formula: | C14H21N5O2.HCl |
| Mol. Weight: | 327.81 g/mol |
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Additional information on CAS 81403-69-2
Parent drug
AlfuzosinIUPAC Name
N-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-N-methylpropane-1,3-diamine hydrochloride; deacylated alfuzosinSynonyms
Alfuzosin Deacylated ImpurityPharmacopeial Synonyms
Alfuzosin Related Compound DSmiles
NCCCN(C1=NC(N)=C2C=C(OC)C(OC)=CC2=N1)C.[H]ClInChI
InChI=1S/C14H21N5O2.ClH/c1-19(6-4-5-15)14-17-10-8-12(21-3)11(20-2)7-9(10)13(16)18-14;/h7-8H,4-6,15H2,1-3H3,(H2,16,17,18);1HDescription
Alfuzosin EP Impurity D, also designated Alfuzosin Related Compound D or Alfuzosin Deacylated Impurity, is the hydrochloride salt of a deacylated alfuzosin-related process impurity, CAS 81403-69-2. With formula C14H21N5O2.HCl and molecular weight 327.81 g/mol, it reflects hydrolytic or synthetic loss of the acyl substituent from the parent quinazoline piperazine scaffold. As a structurally related impurity rather than a reactive genotoxic species, it is relevant to impurity profiling and specification setting under pharmacopeial and ICH concepts. Detection typically relies on LC-MS/MS for trace-level confirmation, supported by HPLC-UV and, where needed, high-resolution mass spectrometry.References
Žuvela, Petar, et al. “Assessment of Column Selection Systems Using Partial Least Squares.â€Â Journal of Chromatography A, vol. 1420, Nov. 2015, pp. 74–82,  https://doi.org/10.1016/j.chroma.2015.09.085.Request a Quote
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