119193-19-0: Alvimopan Impurity 27
Alvimopan Impurity 27 (CAS No: 119193-19-0) or [(3R,4R)-3,4-Dimethylpiperidin-4-yl]phenol is formed by degradation of alvimopan that acts peripherally by antagonist mu-opioid receptor (PAM-OR) and is utilized in the treatment of postoperative ileus.
3-((3R, 4R)-3, 4-dimethylpiperidin-4-yl)phenol
[(3R, 4R)-3, 4-Dimethylpiperidin-4-yl]phenol
Baira, Shandilya Mahamuni, et al. “Identification and Structural Characterization of Hydrolytic Degradation Products of Alvimopan by LC/QTOF/MS/MS and NMR Studies.” Journal of Pharmaceutical and Biomedical Analysis, vol. 165, Feb. 2019, pp. 399–409, https://doi.org/10.1016/j.jpba.2018.12.035.