Alvimopan Impurities

Alvimopan is used to assist the colon to heal faster after surgery, allowing you to eat solid foods and have regular bowel movements.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Alvimopan Acyl-β-D-Glucuronide Alvimopan

Alvimopan Acyl-β-D-Glucuronide

VL5980017 1260616-95-2
Alvimopan DMP Ester Impurity Alvimopan

Alvimopan DMP Ester Impurity

VE0017726 1314751-88-6
Alvimopan Impurity 1 Alvimopan

Alvimopan Impurity 1

VL5980021 170098-42-7
Alvimopan Impurity 11 Alvimopan

Alvimopan Impurity 11

VL5980014 2250243-53-7
Alvimopan Impurity 12 Alvimopan

Alvimopan Impurity 12

VL5980015 59381-63-4
Alvimopan Impurity 13 Alvimopan

Alvimopan Impurity 13

VL5980016 2165896-76-2
Alvimopan Impurity 14 Alvimopan

Alvimopan Impurity 14

VE007904 76932-18-8
Alvimopan Impurity 15 Alvimopan

Alvimopan Impurity 15

VE007905 N/A
Alvimopan Impurity 20 Alvimopan

Alvimopan Impurity 20

VE007907 1314751-83-1
Alvimopan Impurity 21 Alvimopan

Alvimopan Impurity 21

VE007908 660848-81-7
Alvimopan Impurity 22 Alvimopan

Alvimopan Impurity 22

VE007909 1852472-89-9
Alvimopan Impurity 23 Alvimopan

Alvimopan Impurity 23

VE007910 1314751-81-9
Alvimopan Impurity 24 Alvimopan

Alvimopan Impurity 24

VE007911 1237735-54-4
Alvimopan Impurity 25 Alvimopan

Alvimopan Impurity 25

VE007912 2184736-45-4
Alvimopan Impurity 26 Alvimopan

Alvimopan Impurity 26

VE007913 1314751-85-3
Alvimopan Impurity 27 Alvimopan

Alvimopan Impurity 27

VE007914 119193-19-0
Alvimopan Impurity 28 Alvimopan

Alvimopan Impurity 28

VE007915 145678-87-1
Alvimopan Impurity 6 Alvimopan

Alvimopan Impurity 6

VL5980005 1420776-96-0
Alvimopan Impurity 7 Alvimopan

Alvimopan Impurity 7

VL5980006 170098-29-0
Alvimopan Impurity 8 Alvimopan

Alvimopan Impurity 8

VL5980007 660848-91-9
Alvimopan Isomer (2R, 3R, 4R) Alvimopan

Alvimopan Isomer (2R, 3R, 4R)

VL5980008 342639-35-4
Alvimopan Isomer (2R, 3S, 4S) Alvimopan

Alvimopan Isomer (2R, 3S, 4S)

VL5980009 156130-44-8
Alvimopan Isomer (2S, 3S, 4S) Alvimopan

Alvimopan Isomer (2S, 3S, 4S)

VL5980010 2280857-23-8
Alvimopan Metabolite Alvimopan

Alvimopan Metabolite

VL5980020 156130-41-5
Alvimopan Phenolic Glucuronide Alvimopan

Alvimopan Phenolic Glucuronide

VE007857 N/A
Alvimopan-D5 Metabolite HCl (Mixture of Diastereomers) Alvimopan

Alvimopan-D5 Metabolite HCl (Mixture of Diastereomers)

DVE00138 N/A
Phenyl 4-(3-isopropoxyphenyl)-3, 4-dimethylpiperidine-1-carboxylate Alvimopan

Phenyl 4-(3-isopropoxyphenyl)-3, 4-dimethylpiperidine-1-carboxylate

VE009795 N/A
rac-Alvimopan-D5 (Mixture of Diastereomers) Alvimopan

rac-Alvimopan-D5 (Mixture of Diastereomers)

DVE00137 N/A
(3R,4S)-1,2,3,4-Tetrahydro-4-(3-isopropoxyphenyl)-1,3,4-trimethylpyridine Alvimopan

(3R,4S)-1,2,3,4-Tetrahydro-4-(3-isopropoxyphenyl)-1,3,4-trimethylpyridine

VE009793 143919-33-9
(R)-1,2,3,6-Tetrahydro-4-(3-isopropoxyphenyl)-1,3-dimethylpyridine Alvimopan

(R)-1,2,3,6-Tetrahydro-4-(3-isopropoxyphenyl)-1,3-dimethylpyridine

VE009792 143919-32-8
(S)-ethyl 2-(2-benzyl-3-hydroxypropanamido)acetate Alvimopan

(S)-ethyl 2-(2-benzyl-3-hydroxypropanamido)acetate

VE009797 1431697-70-9
[3-(3R, 4R)-1, 3, 4-trimethylpiperidine-4yl-]-phenol Alvimopan

[3-(3R, 4R)-1, 3, 4-trimethylpiperidine-4yl-]-phenol

VE009791 N/A
2-((S)-2-(((3R,4R)-4-(4-Bromo-3-hydroxyphenyl)-3-4-dimethylpiperidin-1-yl)methyl)-3-phenylpropanamido)acetic Acid Alvimopan

2-((S)-2-(((3R,4R)-4-(4-Bromo-3-hydroxyphenyl)-3-4-dimethylpiperidin-1-yl)methyl)-3-phenylpropanamido)acetic Acid

VE009798 N/A
3-((3R,4S)-3,4-dimethylpiperidin-4-yl)phenol compound with 3-((3S,4R)-3,4-dimethylpiperidin-4-yl)phenol (1:1) Alvimopan

3-((3R,4S)-3,4-dimethylpiperidin-4-yl)phenol compound with 3-((3S,4R)-3,4-dimethylpiperidin-4-yl)phenol (1:1)

VE009796 N/A
4-(3-Isopropoxy-phenyl)-1,3,4-trimethyl-piperidine (HCl Salt) Alvimopan

4-(3-Isopropoxy-phenyl)-1,3,4-trimethyl-piperidine (HCl Salt)

VE009794 N/A

Alvimopan Related Compound

Alvimopan is an opioid antagonist that is used to shorten the healing period of the upper and lower gastrointestinal tracts after colon resection with primary anastomosis surgery.

References

  • “Alvimopan: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2023, go.drugbank.com/drugs/DB06274. Accessed 3 July 2023.
  • “Alvimopan: MedlinePlus Drug Information.” Medlineplus.gov, 2023, medlineplus.gov/druginfo/meds/a608051.html#:~:text=Alvimopan%20is%20in%20a%20class,acting%20mu%2Dopioid%20receptor%20antagonists. Accessed 3 July 2023.

FAQ

What is the therapeutic effect of alvimopan?

Alvimopan belongs to a class of drugs known as peripherally acting mu-opioid receptor antagonists. It works by preventing constipation caused by opioid (narcotic) drugs used to alleviate pain following surgery.

What is the mechanism of action of alvimopan?

Alvimopan is an opioid antagonist that is used to shorten the healing period of the upper and lower gastrointestinal tracts after colon resection with primary anastomosis surgery.is an opioid antagonist with a peripheral action.

Which drug class does alvimopan belong to?

Alvimopan belongs to a class of drugs known as peripherally acting mu-opioid receptor antagonists.