Stock Locations

New Jersey, USA
Czech Republic, EU
Mumbai, India

* Stock subject to availability.

Documentation

Download MSDS

Download Sample COA

Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

430433-40-2Berberine Impurity 1 (HCl Salt)

● In Stock

Catalogue No.:	VE0025809
CAS No.:	430433-40-2
Mol. Formula:	C18H21NO4. HCl
Mol. Weight:	315.37 36.46 g/mol

Request a quote

Add to RFQ list

Additional information on CAS 430433-40-2

Parent drug

Berberine

IUPAC Name

2-(benzo[d][1,3]dioxol-5-yl)-N-(2,3-dimethoxybenzyl)ethan-1-amine, hydrochloride (1:1)

Smiles

COC1=C(OC)C(CNCCC2=CC=C(OCO3)C3=C2)=CC=C1.[H]Cl

InChI

InChI=1S/C18H21NO4.ClH/c1-20-16-5-3-4-14(18(16)21-2)11-19-9-8-13-6-7-15-17(10-13)23-12-22-15;/h3-7,10,19H,8-9,11-12H2,1-2H3;1H

Description

Berberine Impurity 1 (HCl Salt) (CAS 430433-40-2) is a characterized process-related impurity encountered during berberine hydrochloride synthesis and downstream processing. Structurally related to the parent alkaloid, this impurity affects impurity profile and requires targeted control by validated HPLC and LC-MS/MS methods for accurate quantification. It exhibits moderate aqueous solubility as the hydrochloride salt and may influence batch stability and crystallization behavior, necessitating monitoring under ICH stress conditions. Suppliers and quality units should implement robust specification limits, orthogonal analytical confirmation, and isolation for reference standard preparation to mitigate risk to product quality and regulatory compliance.