910297-52-8: Dasatinib N-Oxide

910297-52-8: Dasatinib N-Oxide

Dasatinib N-Oxide (CAS No.: 910297-52-8) is a biotransformation product of Dasatinib which is an orally administered small-molecule blocker of an array of tyrosine kinases amongst which are BCR-ABL and SRC family kinases that are evaluated for the treatment of adults with naive chronic-phase chronic myeloid leukemia (CML).

Additional information on CAS 910297-52-8

Catalogue No.

VL4870001
CAS No.

910297-52-8
Molecular Formula

C22H26ClN7O3S
Molecular Weight

504.00 g/mol
Parent drug

Dasatinib
IUPAC Name

4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)-1-(2-hydroxyethyl)piperazine 1-oxide
Synonyms

N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide N-Oxide;
References

Christopher, Lisa J., et al. “Metabolism and Disposition of Dasatinib after Oral Administration to Humans.” Drug Metabolism and Disposition, vol. 36, no. 7, Apr. 2008, pp. 1357–64, https://doi.org/10.1124/dmd.107.018267.?McCormack, Paul L., and Susan J. Keam. “Dasatinib.” Drugs, vol. 71, no. 13, Sept. 2011, pp. 1771–95, https://doi.org/10.2165/11207580-000000000-00000.
Status

In-stock

Other products related to dasatinib

[rfq_list]

Login first to add product to RFQ List

Request a quote

910297-52-8: Dasatinib N-Oxide

910297-52-8: Dasatinib N-Oxide
Catalogue No.

VL4870001
CAS No.

910297-52-8
Molecular Formula

C22H26ClN7O3S
Molecular Weight

504.00 g/mol
Parent drug

Dasatinib
IUPAC Name

4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)-1-(2-hydroxyethyl)piperazine 1-oxide
Synonyms

N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide N-Oxide;
References

Christopher, Lisa J., et al. “Metabolism and Disposition of Dasatinib after Oral Administration to Humans.” Drug Metabolism and Disposition, vol. 36, no. 7, Apr. 2008, pp. 1357–64, https://doi.org/10.1124/dmd.107.018267.?McCormack, Paul L., and Susan J. Keam. “Dasatinib.” Drugs, vol. 71, no. 13, Sept. 2011, pp. 1771–95, https://doi.org/10.2165/11207580-000000000-00000.
Status

In-stock
ListName

Dasatinib N-Oxide
Exclusively Supplied by Veeprho

Exclusively Supplied by Veeprho

"*" indicates required fields

Hidden
Products quotation
Name
Url
 
Hidden