910297-52-8: Dasatinib N-Oxide
Dasatinib N-Oxide (CAS No.: 910297-52-8) is a biotransformation product of Dasatinib which is an orally administered small-molecule blocker of an array of tyrosine kinases amongst which are BCR-ABL and SRC family kinases that are evaluated for the treatment of adults with naive chronic-phase chronic myeloid leukemia (CML).
Additional information on CAS 910297-52-8
Christopher, Lisa J., et al. “Metabolism and Disposition of Dasatinib after Oral Administration to Humans.” Drug Metabolism and Disposition, vol. 36, no. 7, Apr. 2008, pp. 1357–64, https://doi.org/10.1124/dmd.107.018267.?McCormack, Paul L., and Susan J. Keam. “Dasatinib.” Drugs, vol. 71, no. 13, Sept. 2011, pp. 1771–95, https://doi.org/10.2165/11207580-000000000-00000.
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